| Termin | Heim | Gast | Ergebnis |
|---|---|---|---|
| 03.12.21 20:45 | FC Fulham | AFC Bournemouth | 1:1 |
| 04.12.21 13:30 | Coventry City | West Bromwich Albion | 1:2 |
| 04.12.21 16:00 | Nottingham Forest | Peterborough United | 2:0 |
| 04.12.21 16:00 | FC Reading | Hull City A.F.C. | 1:1 |
| 04.12.21 16:00 | FC Barnsley | Huddersfield Town | 1:1 |
| 04.12.21 16:00 | Blackburn Rovers | Preston North End | 1:0 |
| 04.12.21 16:00 | FC Blackpool | Luton Town | 0:3 |
| 04.12.21 16:00 | Bristol City | Derby County | 1:0 |
| 04.12.21 16:00 | Cardiff City | Sheffield United | 2:3 |
| 04.12.21 16:00 | FC Middlesbrough | Swansea City | 1:0 |
| 04.12.21 16:00 | FC Millwall | Birmingham City | 3:1 |
| 05.12.21 15:30 | Queens Park Rangers | FC Stoke City | 0:2 |