Spielplan
| Wettbewerb | Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|---|
| MLS | 05.05.22 01:30 | 05.05.22 01:30 | Cincinnati FC | Toronto FC | 2:0 | 4 - 5 - 4 |
| MLS | 19.05.22 01:30 | 19.05.22 01:30 | D.C. United | New York City FC | 0:2 | 5 - 5 - 3 |
| MLS | 19.05.22 01:30 | 19.05.22 01:30 | Philadelphia Union | Inter Miami CF | 0:0 | 3 - 5 - 5 |
| MLS | 19.05.22 01:30 | 19.05.22 01:30 | New York Red Bulls | Chicago Fire | 3:3 | 3 - 5 - 5 |
| MLS | 19.05.22 02:00 | 19.05.22 02:00 | Minnesota United FC | Los Angeles Galaxy | 1:1 | 5 - 5 - 3 |
| MLS | 19.05.22 02:30 | 19.05.22 02:30 | Houston Dynamo | Seattle Sounders | 0:1 | 5 - 5 - 3 |
| MLS | 19.05.22 02:30 | 19.05.22 02:30 | Nashville SC | CF Montreal | 2:1 | 3 - 5 - 4 |
| MLS | 19.05.22 02:30 | 19.05.22 02:30 | Sporting Kansas City | Colorado Rapids | 2:1 | 4 - 5 - 4 |
| MLS | 19.05.22 04:00 | 19.05.22 04:00 | Vancouver Whitecaps | FC Dallas | 2:1 | 4 - 5 - 3 |
| MLS | 19.05.22 04:30 | 19.05.22 04:30 | Los Angeles FC | Austin FC | 1:2 | 3 - 5 - 5 |
| MLS | 19.05.22 04:30 | 19.05.22 04:30 | San Jose Earthquakes | Portland Timbers | 3:2 | 5 - 4 - 3 |