Spielplan
| Wettbewerb | Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|---|
| MLS | 30.04.22 19:30 | 30.04.22 19:30 | Houston Dynamo | Austin FC | 1:2 | 3 - 5 - 4 |
| MLS | 30.04.22 21:00 | 30.04.22 21:00 | Toronto FC | Cincinnati FC | 1:2 | 3 - 5 - 5 |
| MLS | 30.04.22 21:30 | 30.04.22 21:30 | Real Salt Lake | Los Angeles Galaxy | 1:0 | 5 - 5 - 3 |
| MLS | 30.04.22 22:00 | 30.04.22 22:00 | CF Montreal | Atlanta United FC | 2:1 | 3 - 4 - 5 |
| MLS | 01.05.22 01:30 | 01.05.22 01:30 | Columbus Crew | D.C. United | 3:0 | 3 - 5 - 5 |
| MLS | 01.05.22 01:30 | 01.05.22 01:30 | Orlando City | Charlotte FC | 2:1 | 3 - 5 - 5 |
| MLS | 01.05.22 01:30 | 01.05.22 01:30 | New England Revolution | Inter Miami CF | 2:0 | 3 - 5 - 5 |
| MLS | 01.05.22 02:00 | 01.05.22 02:00 | Chicago Fire | New York Red Bulls | 1:2 | 4 - 5 - 3 |
| MLS | 01.05.22 02:30 | 01.05.22 02:30 | Sporting Kansas City | FC Dallas | 2:2 | 3 - 5 - 4 |
| MLS | 01.05.22 03:00 | 01.05.22 03:00 | Colorado Rapids | Portland Timbers | 2:0 | 4 - 4 - 4 |
| MLS | 01.05.22 19:00 | 01.05.22 19:00 | New York City FC | San Jose Earthquakes | 3:0 | 3 - 5 - 5 |
| MLS | 01.05.22 22:00 | 01.05.22 22:00 | Nashville SC | Philadelphia Union | 1:1 | 4 - 5 - 3 |
| MLS | 02.05.22 04:00 | 02.05.22 04:00 | Los Angeles FC | Minnesota United FC | 2:0 | 3 - 5 - 5 |
| MLS | 15.06.22 04:30 | 15.06.22 04:30 | Seattle Sounders | Vancouver Whitecaps | 4:0 | 3 - 5 - 5 |