Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 20.11.21 20:30 | 20.11.21 20:30 | Philadelphia Union | New York Red Bulls | 1:0n.V. | 3 - 5 - 4 |
| 20.11.21 23:00 | 20.11.21 23:00 | Sporting Kansas City | Vancouver Whitecaps | 3:1 | 3 - 5 - 5 |
| 21.11.21 21:00 | 21.11.21 21:00 | New York City FC | Atlanta United FC | 2:0 | 3 - 5 - 5 |
| 21.11.21 23:30 | 21.11.21 23:30 | Portland Timbers | Minnesota United FC | 3:1 | 3 - 5 - 4 |
| 24.11.21 02:00 | 24.11.21 02:00 | Nashville SC | Orlando City | 3:1 | 3 - 5 - 5 |
| 24.11.21 04:30 | 24.11.21 04:30 | Seattle Sounders | Real Salt Lake | 5:6n.E. | 3 - 5 - 5 |