Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 02.10.21 21:30 | 02.10.21 21:30 | Austin FC | Real Salt Lake | 2:1 | 3 - 5 - 4 |
| 03.10.21 01:00 | 03.10.21 01:00 | CF Montreal | Atlanta United FC | 2:1 | 4 - 5 - 4 |
| 03.10.21 01:30 | 03.10.21 01:30 | Orlando City | D.C. United | 2:1 | 3 - 5 - 5 |
| 03.10.21 01:30 | 03.10.21 01:30 | Cincinnati FC | New York Red Bulls | 0:1 | 5 - 5 - 3 |
| 03.10.21 02:00 | 03.10.21 02:00 | FC Dallas | Minnesota United FC | 0:0 | 3 - 5 - 4 |
| 03.10.21 04:00 | 03.10.21 04:00 | Vancouver Whitecaps | San Jose Earthquakes | 3:0 | 3 - 5 - 5 |
| 03.10.21 18:00 | 03.10.21 18:00 | New York City FC | Nashville SC | 0:0 | 3 - 5 - 5 |
| 03.10.21 22:00 | 03.10.21 22:00 | Philadelphia Union | Columbus Crew | 3:0 | 3 - 5 - 5 |
| 03.10.21 22:00 | 03.10.21 22:00 | Sporting Kansas City | Houston Dynamo | 4:2 | 3 - 5 - 5 |
| 03.10.21 22:00 | 03.10.21 22:00 | Toronto FC | Chicago Fire | 3:1 | 3 - 5 - 5 |
| 03.10.21 23:30 | 03.10.21 23:30 | Portland Timbers | Inter Miami CF | 1:0 | 3 - 5 - 5 |
| 04.10.21 02:00 | 04.10.21 02:00 | Los Angeles Galaxy | Los Angeles FC | 1:1 | 3 - 5 - 5 |
| 04.10.21 04:00 | 04.10.21 04:00 | Seattle Sounders | Colorado Rapids | 3:0 | 3 - 5 - 5 |