Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 23.09.21 01:30 | 23.09.21 01:30 | Inter Miami CF | Nashville SC | 1:5 | 4 - 5 - 4 |
| 25.09.21 21:30 | 25.09.21 21:30 | Philadelphia Union | Atlanta United FC | 1:0 | 4 - 5 - 4 |
| 26.09.21 01:00 | 26.09.21 01:00 | New England Revolution | Orlando City | 2:1 | 3 - 5 - 5 |
| 26.09.21 01:30 | 26.09.21 01:30 | D.C. United | Cincinnati FC | 4:2 | 3 - 5 - 5 |
| 26.09.21 01:30 | 26.09.21 01:30 | Columbus Crew | CF Montreal | 2:1 | 3 - 5 - 4 |
| 26.09.21 02:00 | 26.09.21 02:00 | New York City FC | New York Red Bulls | 0:1 | 3 - 5 - 4 |
| 26.09.21 02:00 | 26.09.21 02:00 | Minnesota United FC | Houston Dynamo | 2:0 | 3 - 5 - 5 |
| 26.09.21 02:00 | 26.09.21 02:00 | Colorado Rapids | Toronto FC | 0:0 | 3 - 5 - 5 |
| 26.09.21 04:00 | 26.09.21 04:00 | San Jose Earthquakes | Los Angeles FC | 2:0 | 4 - 5 - 3 |
| 26.09.21 04:00 | 26.09.21 04:00 | Vancouver Whitecaps | FC Dallas | 1:0 | 3 - 5 - 5 |
| 26.09.21 04:30 | 26.09.21 04:30 | Portland Timbers | Real Salt Lake | 6:1 | 3 - 5 - 5 |
| 26.09.21 19:00 | 26.09.21 19:00 | Chicago Fire | Nashville SC | 0:0 | 4 - 5 - 4 |
| 27.09.21 01:00 | 27.09.21 01:00 | Sporting Kansas City | Seattle Sounders | 1:2 | 3 - 5 - 4 |
| 27.09.21 03:30 | 27.09.21 03:30 | Austin FC | Los Angeles Galaxy | 2:0 | 4 - 5 - 3 |