Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 04.09.21 01:30 | 04.09.21 01:30 | Philadelphia Union | New England Revolution | 0:1 | 3 - 5 - 4 |
| 15.09.21 01:30 | 15.09.21 01:30 | Columbus Crew | New York Red Bulls | 2:1 | 3 - 5 - 5 |
| 15.09.21 01:30 | 15.09.21 01:30 | New York City FC | FC Dallas | 3:3 | 3 - 5 - 5 |
| 15.09.21 01:30 | 15.09.21 01:30 | Toronto FC | Inter Miami CF | 0:1 | 4 - 5 - 4 |
| 16.09.21 01:00 | 16.09.21 01:00 | Atlanta United FC | Cincinnati FC | 4:0 | 3 - 5 - 5 |
| 16.09.21 01:30 | 16.09.21 01:30 | D.C. United | Chicago Fire | 3:0 | 3 - 5 - 5 |
| 16.09.21 01:30 | 16.09.21 01:30 | Orlando City | CF Montreal | 2:4 | 3 - 5 - 5 |
| 16.09.21 02:30 | 16.09.21 02:30 | Sporting Kansas City | Minnesota United FC | 4:0 | 3 - 5 - 5 |
| 16.09.21 03:00 | 16.09.21 03:00 | Austin FC | Los Angeles FC | 1:2 | 5 - 5 - 3 |
| 16.09.21 04:00 | 16.09.21 04:00 | Portland Timbers | Colorado Rapids | 2:2 | 3 - 5 - 5 |
| 16.09.21 04:30 | 16.09.21 04:30 | San Jose Earthquakes | Real Salt Lake | 3:4 | 3 - 5 - 5 |
| 16.09.21 04:30 | 16.09.21 04:30 | Los Angeles Galaxy | Houston Dynamo | 1:1 | 3 - 5 - 5 |
| 10.10.21 03:00 | 10.10.21 03:00 | Seattle Sounders | Vancouver Whitecaps | 4:1 | 3 - 5 - 5 |