Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 04.09.21 01:30 | 04.09.21 01:30 | Nashville SC | New York City FC | 3:1 | 3 - 5 - 5 |
| 04.09.21 02:00 | 04.09.21 02:00 | Houston Dynamo | Portland Timbers | 0:2 | 4 - 5 - 4 |
| 04.09.21 04:00 | 04.09.21 04:00 | Los Angeles FC | Sporting Kansas City | 4:0 | 4 - 5 - 4 |
| 05.09.21 01:30 | 05.09.21 01:30 | Orlando City | Columbus Crew | 3:2 | 3 - 5 - 5 |
| 05.09.21 02:00 | 05.09.21 02:00 | Cincinnati FC | Inter Miami CF | 0:1 | 3 - 5 - 5 |
| 05.09.21 02:00 | 05.09.21 02:00 | Real Salt Lake | FC Dallas | 3:2 | 3 - 5 - 5 |
| 05.09.21 04:00 | 05.09.21 04:00 | San Jose Earthquakes | Colorado Rapids | 0:1 | 4 - 5 - 4 |