Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 29.07.21 04:30 | 29.07.21 04:30 | Los Angeles FC | Minnesota United FC | 2:2 | 3 - 5 - 5 |
| 31.07.21 01:30 | 31.07.21 01:30 | New York City FC | Columbus Crew | 4:1 | 3 - 5 - 5 |
| 31.07.21 02:00 | 31.07.21 02:00 | Orlando City | Atlanta United FC | 3:2 | 3 - 5 - 5 |
| 31.07.21 04:00 | 31.07.21 04:00 | Los Angeles Galaxy | Portland Timbers | 4:1 | 3 - 5 - 4 |
| 31.07.21 23:00 | 31.07.21 23:00 | Seattle Sounders | San Jose Earthquakes | 0:1 | 3 - 5 - 5 |
| 01.08.21 00:00 | 01.08.21 00:00 | New York Red Bulls | New England Revolution | 2:3 | 4 - 5 - 4 |
| 01.08.21 01:30 | 01.08.21 01:30 | Cincinnati FC | D.C. United | 0:0 | 4 - 5 - 4 |
| 01.08.21 02:00 | 01.08.21 02:00 | Inter Miami CF | CF Montreal | 2:1 | 4 - 5 - 4 |
| 01.08.21 02:30 | 01.08.21 02:30 | Sporting Kansas City | FC Dallas | 1:2 | 3 - 5 - 5 |
| 01.08.21 02:30 | 01.08.21 02:30 | Houston Dynamo | Real Salt Lake | 0:0 | 4 - 5 - 4 |
| 01.08.21 03:00 | 01.08.21 03:00 | Austin FC | Colorado Rapids | 0:1 | 4 - 5 - 4 |
| 01.08.21 04:00 | 01.08.21 04:00 | Vancouver Whitecaps | Minnesota United FC | 2:2 | 4 - 5 - 3 |
| 02.08.21 00:00 | 02.08.21 00:00 | Philadelphia Union | Chicago Fire | 1:1 | 3 - 5 - 5 |
| 02.08.21 01:30 | 02.08.21 01:30 | Toronto FC | Nashville SC | 1:1 | 3 - 5 - 5 |
| 05.09.21 01:00 | 05.09.21 01:00 | Vancouver Whitecaps | Austin FC | 2:1 | 3 - 5 - 5 |