| 18.04.22 16:30 | FC Sion | FC Basel | 0:0 | 3 - 3 - 1 |
| 18.04.22 19:30 | Galatasaray Istanbul | Yeni Malatyaspor | 2:0 | 1 - 3 - 3 |
| 18.04.22 21:30 | Estoril Praia | Sporting Braga | 0:0 | 3 - 3 - 1 |
| 19.04.22 19:00 | RCD Mallorca | Deportivo Alaves | 2:1 | 1 - 3 - 3 |
| 19.04.22 19:00 | Kickers Offenbach | TSG Balingen | 1:1 | 1 - 3 - 3 |
| 19.04.22 19:00 | Energie Cottbus | 1. FC Lokomotive Leipzig | 1:1 | 1 - 2 - 3 |
| 19.04.22 20:45 | Hamburger SV | SC Freiburg | 1:3 | 3 - 3 - 1 |
| 19.04.22 21:00 | FC Liverpool | Manchester United | 4:0 | 1 - 3 - 3 |
| 19.04.22 21:00 | Real Betis Sevilla | FC Elche | 0:1 | 1 - 3 - 3 |
| 19.04.22 21:00 | Inter Mailand | AC Mailand | 3:0 | 1 - 3 - 2 |
| 19.04.22 21:30 | FC Villarreal | FC Valencia | 2:0 | 1 - 3 - 3 |
| 20.04.22 19:00 | Atletico Madrid | FC Granada | 0:0 | 1 - 3 - 3 |
| 20.04.22 20:00 | Celta Vigo | FC Getafe | 0:2 | 1 - 2 - 3 |
| 20.04.22 20:45 | RB Leipzig | 1. FC Union Berlin | 2:1 | 1 - 3 - 3 |
| 20.04.22 20:45 | FC Everton | Leicester City | 1:1 | 2 - 2 - 1 |
| 20.04.22 20:45 | Newcastle United | Crystal Palace | 1:0 | 1 - 2 - 3 |
| 20.04.22 20:45 | FC Chelsea | FC Arsenal | 2:4 | 1 - 3 - 3 |
| 20.04.22 21:00 | Manchester City | Brighton and Hove Albion | 3:0 | 1 - 3 - 3 |
| 20.04.22 21:00 | Juventus Turin | AC Florenz | 2:0 | 1 - 3 - 3 |
| 20.04.22 21:30 | CA Osasuna | Real Madrid | 1:3 | 3 - 3 - 1 |
| 21.04.22 19:00 | Espanyol Barcelona | Rayo Vallecano | 0:1 | 1 - 3 - 3 |
| 21.04.22 19:00 | UD Levante | FC Sevilla | 2:3 | 3 - 3 - 1 |
| 21.04.22 20:00 | FC Cadiz | Athletic Bilbao | 2:3 | 3 - 2 - 1 |
| 21.04.22 20:45 | FC Burnley | FC Southampton | 2:0 | 2 - 2 - 1 |
| 21.04.22 21:30 | Real Sociedad | FC Barcelona | 0:1 | 3 - 3 - 1 |
| 22.04.22 18:00 | RKS Radomiak 1910 SA Radom | Cracovia Krakau | 0:1 | 1 - 2 - 2 |
| 22.04.22 20:00 | FC Twente Enschede | Sparta Rotterdam | 2:0 | 1 - 3 - 3 |
| 22.04.22 20:30 | VfL Wolfsburg | FSV Mainz 05 | 5:0 | 1 - 2 - 3 |
| 22.04.22 20:30 | Zaglebie Lubin | Gornik Zabrze | 2:4 | 2 - 1 - 2 |
| 23.04.22 15:00 | Slask Breslau | Bruk-Bet Termalica Nieciecza | 0:4 | 1 - 3 - 3 |
| 23.04.22 15:30 | RB Leipzig | 1. FC Union Berlin | 1:2 | 1 - 3 - 3 |
| 23.04.22 15:30 | SpVgg Greuther Fürth | Bayer 04 Leverkusen | 1:4 | 3 - 3 - 1 |
| 23.04.22 15:30 | 1. FC Köln | Arminia Bielefeld | 3:1 | 1 - 3 - 3 |
| 23.04.22 15:30 | SC Freiburg | Bor. Mönchengladbach | 3:3 | 1 - 3 - 3 |
| 23.04.22 15:30 | Eintracht Frankfurt | 1899 Hoffenheim | 2:2 | 1 - 2 - 3 |
| 23.04.22 16:30 | NEC Nijmwegen | Ajax Amsterdam | 0:1 | 3 - 3 - 1 |
| 23.04.22 17:30 | Piast Gleiwitz | Jagiellonia Bialystok | 2:1 | 1 - 3 - 3 |
| 23.04.22 18:30 | FC Bayern München | Borussia Dortmund | 3:1 | 1 - 3 - 3 |
| 23.04.22 18:45 | AZ Alkmaar | SC Heerenveen | 2:1 | 1 - 3 - 3 |
| 23.04.22 20:00 | RKC Waalwijk | PEC Zwolle | 0:2 | 1 - 2 - 2 |
| 23.04.22 20:00 | Lechia Danzig | KS Warta Poznan | 2:0 | 1 - 3 - 3 |
| 23.04.22 20:45 | KV Mechelen | Sporting Charleroi | 1:0 | 1 - 3 - 3 |
| 23.04.22 21:00 | Cambuur-Leeuwarden | PSV Eindhoven | 1:2 | 3 - 3 - 1 |
| 23.04.22 22:00 | Real Betis Sevilla | FC Valencia | 6:5n.E./1:190m | 1 - 3 - 2 |
| 24.04.22 12:15 | Willem II Tilburg | Vitesse Arnheim | 1:0 | 3 - 3 - 1 |
| 24.04.22 12:30 | Lech Posen | FKS Stal Mielec | 3:1 | 1 - 3 - 3 |
| 24.04.22 13:30 | FC Brügge | Royal Antwerp FC | 1:0 | 1 - 3 - 3 |
| 24.04.22 14:30 | FC Groningen | Heracles Almelo | 0:1 | 1 - 3 - 3 |
| 24.04.22 14:30 | Feyenoord Rotterdam | FC Utrecht | 2:1 | 1 - 3 - 3 |
| 24.04.22 15:00 | KS Rakow Czestochowa | Gornik Leczna | 2:1 | 1 - 3 - 3 |
| 24.04.22 15:30 | VfL Bochum | FC Augsburg | 0:2 | 1 - 3 - 3 |
| 24.04.22 16:00 | KAA Gent | KRC Genk | 0:1 | 1 - 2 - 3 |
| 24.04.22 16:45 | Fortuna Sittard | Go Ahead Eagles Deventer | 1:0 | 1 - 2 - 2 |
| 24.04.22 17:30 | Hertha BSC | VfB Stuttgart | 2:0 | 2 - 2 - 2 |
| 24.04.22 17:30 | Pogon Stettin | Legia Warschau | 3:1 | 1 - 3 - 2 |
| 24.04.22 18:30 | Royale Union Saint-Gilloise | RSC Anderlecht | 3:1 | 1 - 2 - 2 |
| 24.04.22 21:00 | FC Barcelona | Rayo Vallecano | 0:1 | 1 - 3 - 3 |
| 25.04.22 19:00 | FC Viktoria Köln | SV Meppen | 1:1 | 1 - 2 - 3 |
| 25.04.22 19:00 | Wisla Krakau | Wisla Plock | 3:4 | 1 - 3 - 2 |
| 25.04.22 20:45 | Sassuolo Calcio | Juventus Turin | 1:2 | 3 - 3 - 1 |
| 25.04.22 21:00 | Crystal Palace | Leeds United | 0:0 | 1 - 2 - 2 |
| 26.04.22 18:00 | SpVgg Greuther Fürth II | FC Augsburg II | 3:2 | 1 - 2 - 2 |
| 26.04.22 18:30 | SV Ried | FC Admira Wacker Mödling | 1:1 | 1 - 1 - 3 |
| 26.04.22 18:30 | TSV 1896 Rain | 1. FC Schweinfurt 05 | 2:1 | 3 - 3 - 1 |
