Spielplan
| Wettbewerb | Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|---|
| NFL | 24.09.21 02:20 | 24.09.21 02:20 | Houston Texans | Carolina Panthers | 9:24 | 8 - 9 - 5 |
| NFL | 26.09.21 19:00 | 26.09.21 19:00 | Jacksonville Jaguars | Arizona Cardinals | 19:31 | 9 - 9 - 5 |
| NFL | 26.09.21 19:00 | 26.09.21 19:00 | New England Patriots | New Orleans Saints | 13:28 | 5 - 9 - 7 |
| NFL | 26.09.21 19:00 | 26.09.21 19:00 | Detroit Lions | Baltimore Ravens | 17:19 | 9 - 9 - 5 |
| NFL | 26.09.21 19:00 | 26.09.21 19:00 | Cleveland Browns | Chicago Bears | 26:6 | 5 - 9 - 9 |
| NFL | 26.09.21 19:00 | 26.09.21 19:00 | Pittsburgh Steelers | Cincinnati Bengals | 10:24 | 5 - 9 - 9 |
| NFL | 26.09.21 19:00 | 26.09.21 19:00 | Kansas City Chiefs | Los Angeles Chargers | 24:30 | 5 - 9 - 9 |
| NFL | 26.09.21 19:00 | 26.09.21 19:00 | New York Giants | Atlanta Falcons | 14:17 | 6 - 9 - 6 |
| NFL | 26.09.21 19:00 | 26.09.21 19:00 | Tennessee Titans | Indianapolis Colts | 25:16 | 5 - 9 - 9 |
| NFL | 26.09.21 19:00 | 26.09.21 19:00 | Buffalo Bills | Washington Football Team | 43:21 | 5 - 9 - 9 |
| NFL | 26.09.21 22:05 | 26.09.21 22:05 | Las Vegas Raiders | Miami Dolphins | 31:28OT | 5 - 9 - 8 |
| NFL | 26.09.21 22:05 | 26.09.21 22:05 | Denver Broncos | New York Jets | 26:0 | 5 - 9 - 9 |
| NFL | 26.09.21 22:25 | 26.09.21 22:25 | Los Angeles Rams | Tampa Bay Buccaneers | 34:24 | 9 - 9 - 5 |
| NFL | 26.09.21 22:25 | 26.09.21 22:25 | Minnesota Vikings | Seattle Seahawks | 30:17 | 7 - 9 - 5 |
| NFL | 27.09.21 02:20 | 27.09.21 02:20 | San Francisco 49ers | Green Bay Packers | 28:30 | 5 - 9 - 7 |
| NFL | 28.09.21 02:15 | 28.09.21 02:15 | Dallas Cowboys | Philadelphia Eagles | 41:21 | 5 - 9 - 8 |