Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 20.11.21 13:30 | 20.11.21 13:30 | Leicester City | FC Chelsea | 0:3 | 6 - 4 - 1 |
| 20.11.21 16:00 | 20.11.21 16:00 | Wolverhampton Wanderers | West Ham United | 1:0 | 4 - 3 - 2 |
| 20.11.21 16:00 | 20.11.21 16:00 | FC Burnley | Crystal Palace | 3:3 | 3 - 3 - 3 |
| 20.11.21 16:00 | 20.11.21 16:00 | Newcastle United | Brentford FC | 3:3 | 2 - 3 - 3 |
| 20.11.21 16:00 | 20.11.21 16:00 | Norwich City | FC Southampton | 2:1 | 4 - 4 - 2 |
| 20.11.21 16:00 | 20.11.21 16:00 | FC Watford | Manchester United | 4:1 | 8 - 6 - 1 |
| 20.11.21 16:00 | 20.11.21 16:00 | Aston Villa | Brighton and Hove Albion | 2:0 | 3 - 3 - 3 |
| 20.11.21 18:30 | 20.11.21 18:30 | FC Liverpool | FC Arsenal | 4:0 | 1 - 4 - 8 |
| 21.11.21 15:00 | 21.11.21 15:00 | Manchester City | FC Everton | 3:0 | 1 - 8 - 8 |
| 21.11.21 17:30 | 21.11.21 17:30 | Tottenham Hotspur | Leeds United | 2:1 | 1 - 4 - 7 |