Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 08.10.21 02:20 | 08.10.21 02:20 | Seattle Seahawks | Los Angeles Rams | 17:26 | 1 Punkt |
| 10.10.21 15:30 | 10.10.21 15:30 | Atlanta Falcons | New York Jets | 27:20 | 1 Punkt |
| 10.10.21 19:00 | 10.10.21 19:00 | Jacksonville Jaguars | Tennessee Titans | 19:37 | 1 Punkt |
| 10.10.21 19:00 | 10.10.21 19:00 | Carolina Panthers | Philadelphia Eagles | 18:21 | 1 Punkt |
| 10.10.21 19:00 | 10.10.21 19:00 | Pittsburgh Steelers | Denver Broncos | 27:19 | 1 Punkt |
| 10.10.21 19:00 | 10.10.21 19:00 | Cincinnati Bengals | Green Bay Packers | 22:25OT | 1 Punkt |
| 10.10.21 19:00 | 10.10.21 19:00 | Tampa Bay Buccaneers | Miami Dolphins | 45:17 | 1 Punkt |
| 10.10.21 19:00 | 10.10.21 19:00 | Houston Texans | New England Patriots | 22:25 | 1 Punkt |
| 10.10.21 19:00 | 10.10.21 19:00 | Washington Football Team | New Orleans Saints | 22:33 | 1 Punkt |
| 10.10.21 19:00 | 10.10.21 19:00 | Minnesota Vikings | Detroit Lions | 19:17 | 1 Punkt |
| 10.10.21 22:05 | 10.10.21 22:05 | Los Angeles Chargers | Cleveland Browns | 47:42 | 1 Punkt |
| 10.10.21 22:05 | 10.10.21 22:05 | Las Vegas Raiders | Chicago Bears | 9:20 | 1 Punkt |
| 10.10.21 22:25 | 10.10.21 22:25 | Dallas Cowboys | New York Giants | 44:20 | 1 Punkt |
| 10.10.21 22:25 | 10.10.21 22:25 | Arizona Cardinals | San Francisco 49ers | 17:10 | 1 Punkt |
| 11.10.21 02:20 | 11.10.21 02:20 | Kansas City Chiefs | Buffalo Bills | 20:38 | 1 Punkt |
| 12.10.21 02:15 | 12.10.21 02:15 | Baltimore Ravens | Indianapolis Colts | 31:25OT | 1 Punkt |