Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 12.11.21 02:20 | 12.11.21 02:20 | Miami Dolphins | Baltimore Ravens | 22:10 | 1 Punkt |
| 14.11.21 19:00 | 14.11.21 19:00 | New England Patriots | Cleveland Browns | 45:7 | 1 Punkt |
| 14.11.21 19:00 | 14.11.21 19:00 | Pittsburgh Steelers | Detroit Lions | 16:16OT | 1 Punkt |
| 14.11.21 19:00 | 14.11.21 19:00 | Indianapolis Colts | Jacksonville Jaguars | 23:17 | 1 Punkt |
| 14.11.21 19:00 | 14.11.21 19:00 | Tennessee Titans | New Orleans Saints | 23:21 | 1 Punkt |
| 14.11.21 19:00 | 14.11.21 19:00 | Dallas Cowboys | Atlanta Falcons | 43:3 | 1 Punkt |
| 14.11.21 19:00 | 14.11.21 19:00 | Washington Football Team | Tampa Bay Buccaneers | 29:19 | 1 Punkt |
| 14.11.21 19:00 | 14.11.21 19:00 | New York Jets | Buffalo Bills | 17:45 | 1 Punkt |
| 14.11.21 22:05 | 14.11.21 22:05 | Arizona Cardinals | Carolina Panthers | 10:34 | 1 Punkt |
| 14.11.21 22:05 | 14.11.21 22:05 | Los Angeles Chargers | Minnesota Vikings | 20:27 | 1 Punkt |
| 14.11.21 22:25 | 14.11.21 22:25 | Green Bay Packers | Seattle Seahawks | 17:0 | 1 Punkt |
| 14.11.21 22:25 | 14.11.21 22:25 | Denver Broncos | Philadelphia Eagles | 13:30 | 1 Punkt |
| 15.11.21 02:20 | 15.11.21 02:20 | Las Vegas Raiders | Kansas City Chiefs | 14:41 | 1 Punkt |
| 16.11.21 02:15 | 16.11.21 02:15 | San Francisco 49ers | Los Angeles Rams | 31:10 | 1 Punkt |