| Termin | Heim | Gast | Ergebnis |
|---|---|---|---|
| 09.05.21 21:00 | Portland Timbers | Seattle Sounders | 1:2 |
| 13.05.21 01:00 | Toronto FC | Columbus Crew | 2:0 |
| 13.05.21 01:30 | Inter Miami CF | CF Montreal | 0:2 |
| 13.05.21 01:30 | Philadelphia Union | New England Revolution | 1:1 |
| 13.05.21 02:30 | Houston Dynamo | Sporting Kansas City | 1:0 |
| 13.05.21 03:00 | Minnesota United FC | Vancouver Whitecaps | 1:0 |
| 13.05.21 04:30 | San Jose Earthquakes | Seattle Sounders | 0:1 |
| 14.05.21 02:00 | D.C. United | Chicago Fire | 1:0 |
| 15.05.21 19:00 | New York City FC | Toronto FC | 1:1 |
| 15.05.21 21:30 | Los Angeles Galaxy | Austin FC | 2:0 |
| 16.05.21 01:00 | Atlanta United FC | CF Montreal | 1:0 |
| 16.05.21 01:30 | Philadelphia Union | New York Red Bulls | 1:0 |
| 16.05.21 02:00 | Minnesota United FC | FC Dallas | 1:0 |
| 16.05.21 03:00 | Colorado Rapids | Houston Dynamo | 3:1 |
| 16.05.21 03:30 | Real Salt Lake | Nashville SC | 0:0 |
| 16.05.21 04:00 | San Jose Earthquakes | Portland Timbers | 0:2 |
| 16.05.21 20:00 | Sporting Kansas City | Vancouver Whitecaps | 3:0 |
| 16.05.21 22:00 | Cincinnati FC | Inter Miami CF | 2:3 |
| 17.05.21 00:00 | New England Revolution | Columbus Crew | 1:0 |
| 17.05.21 02:00 | D.C. United | Orlando City | 0:1 |
| 17.05.21 03:30 | Seattle Sounders | Los Angeles FC | 2:0 |