Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 14.10.22 02:15 | 14.10.22 02:15 | Chicago Bears | Washington Commanders | 7:12 | 4 - 7 - 6 |
| 16.10.22 19:00 | 16.10.22 19:00 | Pittsburgh Steelers | Tampa Bay Buccaneers | 20:18 | 7 - 7 - 4 |
| 16.10.22 19:00 | 16.10.22 19:00 | New Orleans Saints | Cincinnati Bengals | 26:30 | 5 - 7 - 4 |
| 16.10.22 19:00 | 16.10.22 19:00 | New York Giants | Baltimore Ravens | 24:20 | 5 - 7 - 4 |
| 16.10.22 19:00 | 16.10.22 19:00 | Green Bay Packers | New York Jets | 10:27 | 4 - 7 - 7 |
| 16.10.22 19:00 | 16.10.22 19:00 | Miami Dolphins | Minnesota Vikings | 16:24 | 5 - 7 - 4 |
| 16.10.22 19:00 | 16.10.22 19:00 | Indianapolis Colts | Jacksonville Jaguars | 34:27 | 5 - 7 - 5 |
| 16.10.22 19:00 | 16.10.22 19:00 | Atlanta Falcons | San Francisco 49ers | 28:14 | 7 - 7 - 4 |
| 16.10.22 19:00 | 16.10.22 19:00 | Cleveland Browns | New England Patriots | 15:38 | 5 - 7 - 5 |
| 16.10.22 22:05 | 16.10.22 22:05 | Seattle Seahawks | Arizona Cardinals | 19:9 | 5 - 7 - 5 |
| 16.10.22 22:05 | 16.10.22 22:05 | Los Angeles Rams | Carolina Panthers | 24:10 | 4 - 7 - 7 |
| 16.10.22 22:25 | 16.10.22 22:25 | Kansas City Chiefs | Buffalo Bills | 20:24 | 5 - 7 - 5 |
| 17.10.22 02:20 | 17.10.22 02:20 | Philadelphia Eagles | Dallas Cowboys | 26:17 | 4 - 7 - 6 |
| 18.10.22 02:15 | 18.10.22 02:15 | Los Angeles Chargers | Denver Broncos | 19:16OT | 4 - 7 - 7 |