Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 07.10.22 02:15 | 07.10.22 02:15 | Denver Broncos | Indianapolis Colts | 9:12OT | 4 - 7 - 6 |
| 09.10.22 15:30 | 09.10.22 15:30 | Green Bay Packers | New York Giants | 22:27 | 4 - 7 - 7 |
| 09.10.22 19:00 | 09.10.22 19:00 | Buffalo Bills | Pittsburgh Steelers | 38:3 | 4 - 7 - 7 |
| 09.10.22 19:00 | 09.10.22 19:00 | Tampa Bay Buccaneers | Atlanta Falcons | 21:15 | 4 - 7 - 7 |
| 09.10.22 19:00 | 09.10.22 19:00 | Washington Commanders | Tennessee Titans | 17:21 | 7 - 7 - 4 |
| 09.10.22 19:00 | 09.10.22 19:00 | New Orleans Saints | Seattle Seahawks | 39:32 | 5 - 7 - 5 |
| 09.10.22 19:00 | 09.10.22 19:00 | New York Jets | Miami Dolphins | 40:17 | 7 - 7 - 4 |
| 09.10.22 19:00 | 09.10.22 19:00 | Cleveland Browns | Los Angeles Chargers | 28:30 | 5 - 7 - 4 |
| 09.10.22 19:00 | 09.10.22 19:00 | New England Patriots | Detroit Lions | 29:0 | 5 - 7 - 5 |
| 09.10.22 19:00 | 09.10.22 19:00 | Minnesota Vikings | Chicago Bears | 29:22 | 4 - 7 - 7 |
| 09.10.22 19:00 | 09.10.22 19:00 | Jacksonville Jaguars | Houston Texans | 6:13 | 4 - 7 - 7 |
| 09.10.22 22:05 | 09.10.22 22:05 | Carolina Panthers | San Francisco 49ers | 15:37 | 7 - 7 - 4 |
| 09.10.22 22:25 | 09.10.22 22:25 | Arizona Cardinals | Philadelphia Eagles | 17:20 | 6 - 7 - 4 |
| 09.10.22 22:25 | 09.10.22 22:25 | Los Angeles Rams | Dallas Cowboys | 10:22 | 4 - 7 - 6 |
| 10.10.22 02:20 | 10.10.22 02:20 | Baltimore Ravens | Cincinnati Bengals | 19:17 | 4 - 7 - 5 |
| 11.10.22 02:15 | 11.10.22 02:15 | Kansas City Chiefs | Las Vegas Raiders | 30:29 | 4 - 7 - 7 |