Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 30.09.22 02:15 | 30.09.22 02:15 | Cincinnati Bengals | Miami Dolphins | 27:15 | 5 - 7 - 4 |
| 02.10.22 15:30 | 02.10.22 15:30 | New Orleans Saints | Minnesota Vikings | 25:28 | 5 - 7 - 4 |
| 02.10.22 19:00 | 02.10.22 19:00 | Houston Texans | Los Angeles Chargers | 24:34 | 7 - 7 - 4 |
| 02.10.22 19:00 | 02.10.22 19:00 | Indianapolis Colts | Tennessee Titans | 17:24 | 5 - 7 - 5 |
| 02.10.22 19:00 | 02.10.22 19:00 | Detroit Lions | Seattle Seahawks | 45:48 | 4 - 7 - 6 |
| 02.10.22 19:00 | 02.10.22 19:00 | Baltimore Ravens | Buffalo Bills | 20:23 | 6 - 7 - 4 |
| 02.10.22 19:00 | 02.10.22 19:00 | Dallas Cowboys | Washington Commanders | 25:10 | 4 - 7 - 7 |
| 02.10.22 19:00 | 02.10.22 19:00 | Atlanta Falcons | Cleveland Browns | 23:20 | 6 - 7 - 4 |
| 02.10.22 19:00 | 02.10.22 19:00 | New York Giants | Chicago Bears | 20:12 | 4 - 7 - 5 |
| 02.10.22 19:00 | 02.10.22 19:00 | Pittsburgh Steelers | New York Jets | 20:24 | 4 - 7 - 7 |
| 02.10.22 19:00 | 02.10.22 19:00 | Philadelphia Eagles | Jacksonville Jaguars | 29:21 | 4 - 7 - 7 |
| 02.10.22 22:05 | 02.10.22 22:05 | Carolina Panthers | Arizona Cardinals | 16:26 | 6 - 7 - 4 |
| 02.10.22 22:25 | 02.10.22 22:25 | Las Vegas Raiders | Denver Broncos | 32:23 | 5 - 7 - 5 |
| 02.10.22 22:25 | 02.10.22 22:25 | Green Bay Packers | New England Patriots | 27:24OT | 4 - 7 - 7 |
| 03.10.22 02:20 | 03.10.22 02:20 | Tampa Bay Buccaneers | Kansas City Chiefs | 31:41 | 5 - 7 - 4 |
| 04.10.22 02:15 | 04.10.22 02:15 | San Francisco 49ers | Los Angeles Rams | 24:9 | 6 - 7 - 4 |