Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 23.09.22 02:15 | 23.09.22 02:15 | Cleveland Browns | Pittsburgh Steelers | 29:17 | 5 - 7 - 5 |
| 25.09.22 19:00 | 25.09.22 19:00 | Washington Commanders | Philadelphia Eagles | 8:24 | 7 - 7 - 4 |
| 25.09.22 19:00 | 25.09.22 19:00 | Tennessee Titans | Las Vegas Raiders | 24:22 | 6 - 7 - 4 |
| 25.09.22 19:00 | 25.09.22 19:00 | New England Patriots | Baltimore Ravens | 26:37 | 6 - 7 - 4 |
| 25.09.22 19:00 | 25.09.22 19:00 | New York Jets | Cincinnati Bengals | 12:27 | 7 - 7 - 4 |
| 25.09.22 19:00 | 25.09.22 19:00 | Carolina Panthers | New Orleans Saints | 22:14 | 7 - 7 - 4 |
| 25.09.22 19:00 | 25.09.22 19:00 | Minnesota Vikings | Detroit Lions | 28:24 | 5 - 7 - 5 |
| 25.09.22 19:00 | 25.09.22 19:00 | Miami Dolphins | Buffalo Bills | 21:19 | 7 - 7 - 4 |
| 25.09.22 19:00 | 25.09.22 19:00 | Indianapolis Colts | Kansas City Chiefs | 20:17 | 7 - 7 - 4 |
| 25.09.22 19:00 | 25.09.22 19:00 | Chicago Bears | Houston Texans | 23:20 | 4 - 7 - 6 |
| 25.09.22 22:05 | 25.09.22 22:05 | Los Angeles Chargers | Jacksonville Jaguars | 10:38 | 4 - 7 - 7 |
| 25.09.22 22:25 | 25.09.22 22:25 | Tampa Bay Buccaneers | Green Bay Packers | 12:14 | 4 - 7 - 5 |
| 25.09.22 22:25 | 25.09.22 22:25 | Seattle Seahawks | Atlanta Falcons | 23:27 | 4 - 7 - 5 |
| 25.09.22 22:25 | 25.09.22 22:25 | Arizona Cardinals | Los Angeles Rams | 12:20 | 7 - 7 - 4 |
| 26.09.22 02:20 | 26.09.22 02:20 | Denver Broncos | San Francisco 49ers | 11:10 | 5 - 7 - 4 |
| 27.09.22 02:15 | 27.09.22 02:15 | New York Giants | Dallas Cowboys | 16:23 | 5 - 7 - 5 |