Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 16.09.22 02:15 | 16.09.22 02:15 | Kansas City Chiefs | Los Angeles Chargers | 27:24 | 4 - 7 - 7 |
| 18.09.22 19:00 | 18.09.22 19:00 | New York Giants | Carolina Panthers | 19:16 | 5 - 7 - 5 |
| 18.09.22 19:00 | 18.09.22 19:00 | Jacksonville Jaguars | Indianapolis Colts | 24:0 | 6 - 7 - 4 |
| 18.09.22 19:00 | 18.09.22 19:00 | Cleveland Browns | New York Jets | 30:31 | 4 - 7 - 7 |
| 18.09.22 19:00 | 18.09.22 19:00 | Detroit Lions | Washington Commanders | 36:27 | 4 - 7 - 5 |
| 18.09.22 19:00 | 18.09.22 19:00 | New Orleans Saints | Tampa Bay Buccaneers | 10:20 | 6 - 7 - 4 |
| 18.09.22 19:00 | 18.09.22 19:00 | Pittsburgh Steelers | New England Patriots | 14:17 | 4 - 7 - 5 |
| 18.09.22 19:00 | 18.09.22 19:00 | Baltimore Ravens | Miami Dolphins | 38:42 | 5 - 7 - 5 |
| 18.09.22 22:05 | 18.09.22 22:05 | San Francisco 49ers | Seattle Seahawks | 27:7 | 4 - 7 - 6 |
| 18.09.22 22:05 | 18.09.22 22:05 | Los Angeles Rams | Atlanta Falcons | 31:27 | 4 - 7 - 7 |
| 18.09.22 22:25 | 18.09.22 22:25 | Dallas Cowboys | Cincinnati Bengals | 20:17 | 7 - 7 - 4 |
| 18.09.22 22:25 | 18.09.22 22:25 | Denver Broncos | Houston Texans | 16:9 | 4 - 7 - 7 |
| 18.09.22 22:25 | 18.09.22 22:25 | Las Vegas Raiders | Arizona Cardinals | 23:29OT | 4 - 7 - 5 |
| 19.09.22 02:20 | 19.09.22 02:20 | Green Bay Packers | Chicago Bears | 27:10 | 4 - 7 - 7 |
| 20.09.22 01:15 | 20.09.22 01:15 | Buffalo Bills | Tennessee Titans | 41:7 | 4 - 7 - 7 |
| 20.09.22 02:30 | 20.09.22 02:30 | Philadelphia Eagles | Minnesota Vikings | 24:7 | 5 - 7 - 5 |