Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 09.09.22 02:20 | 09.09.22 02:20 | Los Angeles Rams | Buffalo Bills | 10:31 | 5 - 7 - 5 |
| 11.09.22 19:00 | 11.09.22 19:00 | Miami Dolphins | New England Patriots | 20:7 | 5 - 7 - 5 |
| 11.09.22 19:00 | 11.09.22 19:00 | Houston Texans | Indianapolis Colts | 20:20OT | 7 - 7 - 4 |
| 11.09.22 19:00 | 11.09.22 19:00 | New York Jets | Baltimore Ravens | 9:24 | 7 - 7 - 4 |
| 11.09.22 19:00 | 11.09.22 19:00 | Detroit Lions | Philadelphia Eagles | 35:38 | 6 - 7 - 4 |
| 11.09.22 19:00 | 11.09.22 19:00 | Cincinnati Bengals | Pittsburgh Steelers | 20:23OT | 4 - 7 - 7 |
| 11.09.22 19:00 | 11.09.22 19:00 | Carolina Panthers | Cleveland Browns | 24:26 | 5 - 7 - 5 |
| 11.09.22 19:00 | 11.09.22 19:00 | Chicago Bears | San Francisco 49ers | 19:10 | 7 - 7 - 4 |
| 11.09.22 19:00 | 11.09.22 19:00 | Washington Commanders | Jacksonville Jaguars | 28:22 | 5 - 7 - 5 |
| 11.09.22 19:00 | 11.09.22 19:00 | Atlanta Falcons | New Orleans Saints | 26:27 | 7 - 7 - 4 |
| 11.09.22 22:25 | 11.09.22 22:25 | Minnesota Vikings | Green Bay Packers | 23:7 | 7 - 7 - 4 |
| 11.09.22 22:25 | 11.09.22 22:25 | Arizona Cardinals | Kansas City Chiefs | 21:44 | 7 - 7 - 4 |
| 11.09.22 22:25 | 11.09.22 22:25 | Tennessee Titans | New York Giants | 20:21 | 4 - 7 - 7 |
| 11.09.22 22:25 | 11.09.22 22:25 | Los Angeles Chargers | Las Vegas Raiders | 24:19 | 5 - 7 - 5 |
| 12.09.22 02:20 | 12.09.22 02:20 | Dallas Cowboys | Tampa Bay Buccaneers | 3:19 | 6 - 7 - 4 |
| 13.09.22 02:15 | 13.09.22 02:15 | Seattle Seahawks | Denver Broncos | 17:16 | 6 - 7 - 4 |