Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 03.12.21 02:20 | 03.12.21 02:20 | New Orleans Saints | Dallas Cowboys | 17:27 | 7 - 7 - 4 |
| 05.12.21 19:00 | 05.12.21 19:00 | Atlanta Falcons | Tampa Bay Buccaneers | 17:30 | 7 - 7 - 4 |
| 05.12.21 19:00 | 05.12.21 19:00 | Cincinnati Bengals | Los Angeles Chargers | 22:41 | 4 - 7 - 6 |
| 05.12.21 19:00 | 05.12.21 19:00 | Chicago Bears | Arizona Cardinals | 22:33 | 7 - 7 - 4 |
| 05.12.21 19:00 | 05.12.21 19:00 | New York Jets | Philadelphia Eagles | 18:33 | 7 - 7 - 4 |
| 05.12.21 19:00 | 05.12.21 19:00 | Detroit Lions | Minnesota Vikings | 29:27 | 7 - 7 - 4 |
| 05.12.21 19:00 | 05.12.21 19:00 | Houston Texans | Indianapolis Colts | 0:31 | 7 - 7 - 4 |
| 05.12.21 19:00 | 05.12.21 19:00 | Miami Dolphins | New York Giants | 20:9 | 4 - 7 - 7 |
| 05.12.21 22:05 | 05.12.21 22:05 | Los Angeles Rams | Jacksonville Jaguars | 37:7 | 4 - 7 - 7 |
| 05.12.21 22:05 | 05.12.21 22:05 | Las Vegas Raiders | Washington Football Team | 15:17 | 4 - 7 - 5 |
| 05.12.21 22:25 | 05.12.21 22:25 | Seattle Seahawks | San Francisco 49ers | 30:23 | 6 - 7 - 4 |
| 05.12.21 22:25 | 05.12.21 22:25 | Pittsburgh Steelers | Baltimore Ravens | 20:19 | 7 - 7 - 4 |
| 06.12.21 02:20 | 06.12.21 02:20 | Kansas City Chiefs | Denver Broncos | 22:9 | 4 - 7 - 7 |
| 07.12.21 02:15 | 07.12.21 02:15 | Buffalo Bills | New England Patriots | 10:14 | 5 - 7 - 4 |