Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 29.10.21 02:20 | 29.10.21 02:20 | Arizona Cardinals | Green Bay Packers | 21:24 | 4 - 7 - 5 |
| 31.10.21 18:00 | 31.10.21 18:00 | Buffalo Bills | Miami Dolphins | 26:11 | 4 - 7 - 7 |
| 31.10.21 18:00 | 31.10.21 18:00 | Atlanta Falcons | Carolina Panthers | 13:19 | 4 - 7 - 6 |
| 31.10.21 18:00 | 31.10.21 18:00 | Chicago Bears | San Francisco 49ers | 22:33 | 5 - 7 - 4 |
| 31.10.21 18:00 | 31.10.21 18:00 | Detroit Lions | Philadelphia Eagles | 6:44 | 6 - 7 - 4 |
| 31.10.21 18:00 | 31.10.21 18:00 | Cleveland Browns | Pittsburgh Steelers | 10:15 | 4 - 7 - 6 |
| 31.10.21 18:00 | 31.10.21 18:00 | Houston Texans | Los Angeles Rams | 22:38 | 7 - 7 - 4 |
| 31.10.21 18:00 | 31.10.21 18:00 | Indianapolis Colts | Tennessee Titans | 31:34OT | 7 - 7 - 4 |
| 31.10.21 18:00 | 31.10.21 18:00 | New York Jets | Cincinnati Bengals | 34:31 | 7 - 7 - 4 |
| 31.10.21 21:05 | 31.10.21 21:05 | Seattle Seahawks | Jacksonville Jaguars | 31:7 | 4 - 7 - 7 |
| 31.10.21 21:05 | 31.10.21 21:05 | Los Angeles Chargers | New England Patriots | 24:27 | 4 - 7 - 5 |
| 31.10.21 21:25 | 31.10.21 21:25 | New Orleans Saints | Tampa Bay Buccaneers | 36:27 | 7 - 7 - 4 |
| 31.10.21 21:25 | 31.10.21 21:25 | Denver Broncos | Washington Football Team | 17:10 | 4 - 7 - 5 |
| 01.11.21 01:20 | 01.11.21 01:20 | Minnesota Vikings | Dallas Cowboys | 16:20 | 6 - 7 - 4 |
| 02.11.21 01:15 | 02.11.21 01:15 | Kansas City Chiefs | New York Giants | 20:17 | 4 - 7 - 7 |