Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 17.09.21 02:20 | 17.09.21 02:20 | Washington Football Team | New York Giants | 30:29 | 4 - 7 - 6 |
| 19.09.21 19:00 | 19.09.21 19:00 | Chicago Bears | Cincinnati Bengals | 20:17 | 5 - 7 - 5 |
| 19.09.21 19:00 | 19.09.21 19:00 | Pittsburgh Steelers | Las Vegas Raiders | 17:26 | 4 - 7 - 6 |
| 19.09.21 19:00 | 19.09.21 19:00 | Indianapolis Colts | Los Angeles Rams | 24:27 | 7 - 7 - 4 |
| 19.09.21 19:00 | 19.09.21 19:00 | Philadelphia Eagles | San Francisco 49ers | 11:17 | 7 - 7 - 4 |
| 19.09.21 19:00 | 19.09.21 19:00 | Miami Dolphins | Buffalo Bills | 0:35 | 6 - 7 - 4 |
| 19.09.21 19:00 | 19.09.21 19:00 | Jacksonville Jaguars | Denver Broncos | 13:23 | 6 - 7 - 4 |
| 19.09.21 19:00 | 19.09.21 19:00 | New York Jets | New England Patriots | 6:25 | 7 - 7 - 4 |
| 19.09.21 19:00 | 19.09.21 19:00 | Carolina Panthers | New Orleans Saints | 26:7 | 7 - 7 - 4 |
| 19.09.21 19:00 | 19.09.21 19:00 | Cleveland Browns | Houston Texans | 31:21 | 4 - 7 - 7 |
| 19.09.21 22:05 | 19.09.21 22:05 | Tampa Bay Buccaneers | Atlanta Falcons | 48:25 | 4 - 7 - 7 |
| 19.09.21 22:05 | 19.09.21 22:05 | Arizona Cardinals | Minnesota Vikings | 34:33 | 4 - 7 - 7 |
| 19.09.21 22:25 | 19.09.21 22:25 | Los Angeles Chargers | Dallas Cowboys | 17:20 | 5 - 7 - 4 |
| 19.09.21 22:25 | 19.09.21 22:25 | Seattle Seahawks | Tennessee Titans | 30:33OT | 4 - 7 - 7 |
| 20.09.21 02:20 | 20.09.21 02:20 | Baltimore Ravens | Kansas City Chiefs | 36:35 | 7 - 7 - 4 |
| 21.09.21 02:15 | 21.09.21 02:15 | Green Bay Packers | Detroit Lions | 35:17 | 4 - 7 - 7 |