Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 24.12.21 02:20 | 24.12.21 02:20 | Tennessee Titans | San Francisco 49ers | 20:17 | 5 - 7 - 5 |
| 25.12.21 22:30 | 25.12.21 22:30 | Green Bay Packers | Cleveland Browns | 24:22 | 4 - 7 - 7 |
| 26.12.21 02:15 | 26.12.21 02:15 | Arizona Cardinals | Indianapolis Colts | 16:22 | 5 - 7 - 5 |
| 26.12.21 19:00 | 26.12.21 19:00 | Cincinnati Bengals | Baltimore Ravens | 41:21 | 5 - 7 - 5 |
| 26.12.21 19:00 | 26.12.21 19:00 | Houston Texans | Los Angeles Chargers | 41:29 | 7 - 7 - 4 |
| 26.12.21 19:00 | 26.12.21 19:00 | Atlanta Falcons | Detroit Lions | 20:16 | 4 - 7 - 5 |
| 26.12.21 19:00 | 26.12.21 19:00 | New York Jets | Jacksonville Jaguars | 26:21 | 4 - 7 - 6 |
| 26.12.21 19:00 | 26.12.21 19:00 | Carolina Panthers | Tampa Bay Buccaneers | 6:32 | 7 - 7 - 4 |
| 26.12.21 19:00 | 26.12.21 19:00 | New England Patriots | Buffalo Bills | 21:33 | 4 - 7 - 5 |
| 26.12.21 19:00 | 26.12.21 19:00 | Minnesota Vikings | Los Angeles Rams | 23:30 | 7 - 7 - 4 |
| 26.12.21 19:00 | 26.12.21 19:00 | Philadelphia Eagles | New York Giants | 34:10 | 4 - 7 - 7 |
| 26.12.21 22:05 | 26.12.21 22:05 | Seattle Seahawks | Chicago Bears | 24:25 | 4 - 7 - 7 |
| 26.12.21 22:25 | 26.12.21 22:25 | Las Vegas Raiders | Denver Broncos | 17:13 | 4 - 7 - 5 |
| 26.12.21 22:25 | 26.12.21 22:25 | Kansas City Chiefs | Pittsburgh Steelers | 36:10 | 4 - 7 - 7 |
| 27.12.21 02:20 | 27.12.21 02:20 | Dallas Cowboys | Washington Football Team | 56:14 | 4 - 7 - 7 |
| 28.12.21 02:15 | 28.12.21 02:15 | New Orleans Saints | Miami Dolphins | 3:20 | 4 - 7 - 5 |