Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 25.11.21 18:30 | 25.11.21 18:30 | Detroit Lions | Chicago Bears | 14:16 | 6 - 7 - 4 |
| 25.11.21 22:30 | 25.11.21 22:30 | Dallas Cowboys | Las Vegas Raiders | 33:36OT | 4 - 7 - 7 |
| 26.11.21 02:20 | 26.11.21 02:20 | New Orleans Saints | Buffalo Bills | 6:31 | 6 - 7 - 4 |
| 28.11.21 19:00 | 28.11.21 19:00 | Jacksonville Jaguars | Atlanta Falcons | 14:21 | 6 - 7 - 4 |
| 28.11.21 19:00 | 28.11.21 19:00 | Cincinnati Bengals | Pittsburgh Steelers | 41:10 | 4 - 7 - 5 |
| 28.11.21 19:00 | 28.11.21 19:00 | New England Patriots | Tennessee Titans | 36:13 | 4 - 7 - 6 |
| 28.11.21 19:00 | 28.11.21 19:00 | Miami Dolphins | Carolina Panthers | 33:10 | 6 - 7 - 4 |
| 28.11.21 19:00 | 28.11.21 19:00 | New York Giants | Philadelphia Eagles | 13:7 | 7 - 7 - 4 |
| 28.11.21 19:00 | 28.11.21 19:00 | Houston Texans | New York Jets | 14:21 | 4 - 7 - 6 |
| 28.11.21 19:00 | 28.11.21 19:00 | Indianapolis Colts | Tampa Bay Buccaneers | 31:38 | 6 - 7 - 4 |
| 28.11.21 22:05 | 28.11.21 22:05 | Denver Broncos | Los Angeles Chargers | 28:13 | 7 - 7 - 4 |
| 28.11.21 22:25 | 28.11.21 22:25 | San Francisco 49ers | Minnesota Vikings | 34:26 | 5 - 7 - 5 |
| 28.11.21 22:25 | 28.11.21 22:25 | Green Bay Packers | Los Angeles Rams | 36:28 | 4 - 7 - 5 |
| 29.11.21 02:20 | 29.11.21 02:20 | Baltimore Ravens | Cleveland Browns | 16:10 | 4 - 7 - 7 |
| 30.11.21 02:15 | 30.11.21 02:15 | Washington Football Team | Seattle Seahawks | 17:15 | 5 - 7 - 5 |