Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 04.12.21 01:00 | 04.12.21 00:55 | UTSA Roadrunners | Western Kentucky Hilltoppers | 49:41 | 0 - 3 Punkte |
| 04.12.21 02:00 | 04.12.21 01:55 | Utah Utes | Oregon Ducks | 38:10 | 0 - 3 Punkte |
| 04.12.21 18:00 | 04.12.21 17:55 | Northern Illinois Huskies | Kent State Golden Flashes | 41:23 | 0 - 3 Punkte |
| 04.12.21 18:00 | 04.12.21 17:55 | Oklahoma State Cowboys | Baylor Bears | 16:21 | 0 - 3 Punkte |
| 04.12.21 21:00 | 04.12.21 20:55 | San Diego State Aztecs | Utah State Aggies | 13:46 | 0 - 3 Punkte |
| 04.12.21 21:30 | 04.12.21 21:25 | Louisiana-Lafayette Ragin' Cajuns | Appalachian State Mountaineers | 24:16 | 0 - 3 Punkte |
| 04.12.21 22:00 | 04.12.21 21:55 | Alabama Crimson Tide | Georgia Bulldogs | 41:24 | 0 - 3 Punkte |
| 04.12.21 22:00 | 04.12.21 21:55 | Cincinnati Bearcats | Houston Cougars | 35:20 | 0 - 3 Punkte |
| 05.12.21 02:00 | 05.12.21 01:55 | Wake Forest Demon Deacons | Pittsburgh Panthers | 21:45 | 0 - 3 Punkte |
| 05.12.21 02:00 | 05.12.21 01:55 | Iowa Hawkeyes | Michigan Wolverines | 3:42 | 0 - 3 Punkte |