Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 12.11.21 01:30 | 12.11.21 01:25 | Pittsburgh Panthers | North Carolina Tar Heels | 30:23OT | 0 - 3 Punkte |
| 13.11.21 00:00 | 12.11.21 23:55 | South Florida Bulls | Cincinnati Bearcats | 28:45 | 0 - 3 Punkte |
| 13.11.21 18:00 | 13.11.21 17:55 | Alabama Crimson Tide | New Mexico State Aggies | 59:3 | 0 - 3 Punkte |
| 13.11.21 18:00 | 13.11.21 17:55 | Auburn Tigers | Mississippi State Bulldogs | 34:43 | 0 - 3 Punkte |
| 13.11.21 18:00 | 13.11.21 17:55 | Penn State Nittany Lions | Michigan Wolverines | 17:21 | 0 - 3 Punkte |
| 13.11.21 18:00 | 13.11.21 17:55 | Wisconsin Badgers | Northwestern Wildcats | 35:7 | 0 - 3 Punkte |
| 13.11.21 18:00 | 13.11.21 17:55 | Baylor Bears | Oklahoma Sooners | 27:14 | 0 - 3 Punkte |
| 13.11.21 18:00 | 13.11.21 17:55 | Louisville Cardinals | Syracuse Orange | 41:3 | 0 - 3 Punkte |
| 13.11.21 18:00 | 13.11.21 17:55 | Kansas State Wildcats | West Virginia Mountaineers | 34:17 | 0 - 3 Punkte |
| 13.11.21 20:00 | 13.11.21 19:55 | Arizona Wildcats | Utah Utes | 29:38 | 0 - 3 Punkte |
| 13.11.21 21:30 | 13.11.21 21:25 | Tennessee Volunteers | Georgia Bulldogs | 17:41 | 0 - 3 Punkte |
| 13.11.21 21:30 | 13.11.21 21:25 | UTSA Roadrunners | Southern Miss Golden Eagles | 27:17 | 0 - 3 Punkte |
| 13.11.21 21:30 | 13.11.21 21:25 | Iowa Hawkeyes | Minnesota Golden Gophers | 27:22 | 0 - 3 Punkte |
| 13.11.21 21:30 | 13.11.21 21:25 | Ohio State Buckeyes | Purdue Boilermakers | 59:31 | 0 - 3 Punkte |
| 13.11.21 21:30 | 13.11.21 21:25 | Florida State Seminoles | Miami (FL) Hurricanes | 31:28 | 0 - 3 Punkte |
| 13.11.21 21:30 | 13.11.21 21:25 | Texas Tech Red Raiders | Iowa State Cyclones | 41:38 | 0 - 3 Punkte |
| 13.11.21 22:00 | 13.11.21 21:55 | Michigan State Spartans | Maryland Terrapins | 40:21 | 0 - 3 Punkte |
| 14.11.21 01:00 | 14.11.21 00:55 | Ole Miss Rebels | Texas A&M Aggies | 29:19 | 0 - 3 Punkte |
| 14.11.21 01:30 | 14.11.21 01:25 | LSU Tigers | Arkansas Razorbacks | 13:16OT | 0 - 3 Punkte |
| 14.11.21 01:30 | 14.11.21 01:25 | Virginia Cavaliers | Notre Dame Fighting Irish | 3:28 | 0 - 3 Punkte |
| 14.11.21 01:30 | 14.11.21 01:25 | Wake Forest Demon Deacons | North Carolina State Wolfpack | 45:42 | 0 - 3 Punkte |
| 14.11.21 02:00 | 14.11.21 01:55 | Oklahoma State Cowboys | TCU Horned Frogs | 63:17 | 0 - 3 Punkte |
| 14.11.21 03:00 | 14.11.21 02:55 | UCLA Bruins | Colorado Buffaloes | 44:20 | 0 - 3 Punkte |
| 14.11.21 04:30 | 14.11.21 04:25 | Oregon Ducks | Washington State Cougars | 38:24 | 0 - 3 Punkte |
| 14.11.21 04:30 | 14.11.21 04:25 | San Diego State Aztecs | Nevada Wolf Pack | 23:21 | 0 - 3 Punkte |