Spielplan
| Wettbewerb | Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|---|
| MLS | 23.04.22 21:00 | 23.04.22 21:00 | Philadelphia Union | CF Montreal | 1:1 | 3 - 5 - 5 |
| MLS | 23.04.22 21:00 | 23.04.22 21:00 | FC Dallas | Houston Dynamo | 2:1 | 3 - 5 - 5 |
| MLS | 23.04.22 23:00 | 23.04.22 23:00 | Minnesota United FC | Chicago Fire | 3:0 | 4 - 5 - 4 |
| MLS | 24.04.22 01:30 | 24.04.22 01:30 | D.C. United | New England Revolution | 3:2 | 3 - 5 - 4 |
| MLS | 24.04.22 02:30 | 24.04.22 02:30 | Austin FC | Vancouver Whitecaps | 3:0 | 3 - 5 - 5 |
| MLS | 24.04.22 02:30 | 24.04.22 02:30 | Sporting Kansas City | Columbus Crew | 0:0 | 3 - 5 - 5 |
| MLS | 24.04.22 03:00 | 24.04.22 03:00 | Colorado Rapids | Charlotte FC | 0:0 | 3 - 5 - 4 |
| MLS | 24.04.22 04:00 | 24.04.22 04:00 | Portland Timbers | Real Salt Lake | 0:0 | 3 - 5 - 5 |
| MLS | 24.04.22 04:00 | 24.04.22 04:00 | San Jose Earthquakes | Seattle Sounders | 4:3 | 5 - 5 - 3 |
| MLS | 24.04.22 04:30 | 24.04.22 04:30 | Los Angeles Galaxy | Nashville SC | 1:0 | 3 - 5 - 5 |
| MLS | 24.04.22 19:00 | 24.04.22 19:00 | Inter Miami CF | Atlanta United FC | 2:1 | 5 - 5 - 3 |
| MLS | 24.04.22 21:30 | 24.04.22 21:30 | Orlando City | New York Red Bulls | 0:3 | 4 - 5 - 4 |
| MLS | 24.04.22 23:00 | 24.04.22 23:00 | Cincinnati FC | Los Angeles FC | 1:2 | 5 - 5 - 3 |
| MLS | 24.04.22 23:00 | 24.04.22 23:00 | New York City FC | Toronto FC | 5:4 | 3 - 5 - 5 |