Spielplan
| Wettbewerb | Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|---|
| MLS | 16.04.22 21:00 | 16.04.22 21:00 | CF Montreal | Vancouver Whitecaps | 2:1 | 3 - 5 - 5 |
| MLS | 16.04.22 21:30 | 16.04.22 21:30 | San Jose Earthquakes | Nashville SC | 2:2 | 4 - 5 - 3 |
| MLS | 17.04.22 00:00 | 17.04.22 00:00 | Houston Dynamo | Portland Timbers | 0:0 | 4 - 4 - 4 |
| MLS | 17.04.22 00:00 | 17.04.22 00:00 | Atlanta United FC | Cincinnati FC | 0:0 | 3 - 5 - 5 |
| MLS | 17.04.22 01:00 | 17.04.22 01:00 | New York Red Bulls | FC Dallas | 0:0 | 3 - 5 - 4 |
| MLS | 17.04.22 01:30 | 17.04.22 01:30 | Toronto FC | Philadelphia Union | 2:1 | 4 - 5 - 3 |
| MLS | 17.04.22 01:30 | 17.04.22 01:30 | D.C. United | Austin FC | 2:3 | 3 - 5 - 4 |
| MLS | 17.04.22 01:30 | 17.04.22 01:30 | Columbus Crew | Orlando City | 0:2 | 3 - 5 - 5 |
| MLS | 17.04.22 01:30 | 17.04.22 01:30 | New England Revolution | Charlotte FC | 2:1 | 3 - 5 - 4 |
| MLS | 17.04.22 02:00 | 17.04.22 02:00 | Minnesota United FC | Colorado Rapids | 3:1 | 4 - 4 - 5 |
| MLS | 17.04.22 02:00 | 17.04.22 02:00 | Chicago Fire | Los Angeles Galaxy | 0:0 | 5 - 5 - 3 |
| MLS | 17.04.22 04:00 | 17.04.22 04:00 | Seattle Sounders | Inter Miami CF | 0:1 | 3 - 5 - 5 |
| MLS | 17.04.22 19:00 | 17.04.22 19:00 | New York City FC | Real Salt Lake | 6:0 | 3 - 5 - 5 |
| MLS | 17.04.22 22:00 | 17.04.22 22:00 | Los Angeles FC | Sporting Kansas City | 3:1 | 3 - 5 - 5 |