Spielplan
| Wettbewerb | Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|---|
| MLS | 09.04.22 19:00 | 09.04.22 19:00 | Orlando City | Chicago Fire | 1:0 | 4 - 4 - 4 |
| MLS | 09.04.22 21:00 | 09.04.22 21:00 | Inter Miami CF | New England Revolution | 3:2 | 5 - 5 - 3 |
| MLS | 09.04.22 22:00 | 09.04.22 22:00 | New York Red Bulls | CF Montreal | 1:2 | 3 - 5 - 5 |
| MLS | 10.04.22 00:00 | 10.04.22 00:00 | Philadelphia Union | Columbus Crew | 1:0 | 3 - 5 - 5 |
| MLS | 10.04.22 01:30 | 10.04.22 01:30 | Los Angeles Galaxy | Los Angeles FC | 2:1 | 4 - 4 - 5 |
| MLS | 10.04.22 02:00 | 10.04.22 02:00 | Real Salt Lake | Toronto FC | 2:2 | 3 - 5 - 5 |
| MLS | 10.04.22 02:30 | 10.04.22 02:30 | FC Dallas | Colorado Rapids | 3:1 | 3 - 5 - 5 |
| MLS | 10.04.22 02:30 | 10.04.22 02:30 | Houston Dynamo | San Jose Earthquakes | 4:3 | 3 - 5 - 5 |
| MLS | 10.04.22 02:30 | 10.04.22 02:30 | Sporting Kansas City | Nashville SC | 1:2 | 3 - 5 - 4 |
| MLS | 10.04.22 04:00 | 10.04.22 04:00 | Vancouver Whitecaps | Portland Timbers | 2:3 | 4 - 5 - 3 |
| MLS | 10.04.22 19:30 | 10.04.22 19:30 | Charlotte FC | Atlanta United FC | 1:0 | 5 - 5 - 3 |
| MLS | 11.04.22 01:30 | 11.04.22 01:30 | Austin FC | Minnesota United FC | 1:0 | 3 - 5 - 5 |
| MLS | 01.09.22 02:00 | 01.09.22 02:00 | New York City FC | D.C. United | 1:2 | 3 - 5 - 5 |
| MLS | 28.09.22 04:00 | 28.09.22 04:00 | Seattle Sounders | Cincinnati FC | 1:1 | 3 - 5 - 5 |